王鐘賢 教授

聯絡資訊

 

Tel: 886-3-211-8800 ext 5748

mails5492@mail.cgu.edu.tw

webhttp://163.25.111.82/wang/

 

主要學歷

 

 國立成功大學醫學院基礎醫學研究所 博士
 
國立成功大學醫學院生理研究所 碩士
 
中山醫學院復健醫學系學士

 

專長領域

 

心肺物理治療、運動生理、血栓/發炎免疫

 

學術榮譽

 

1.        榮獲第一屆國家科學會委員會吳大猷先生紀念獎

2.        國家科學會委員會研究傑出獎候選人

3.        國家科學會委員會 [ A ] 主持人研究獎勵

4.        長庚大學 研究優良教師獎

5.        Invited Speaker, The 2nd Asia-Oceanian Conference of Physical and Rehabilitation Medicine

6.        21 SCI 國際性期刊審稿與 3 本國際性期刊編輯。

7.        研究議題主軸為運動處方/低氧介入對健康促進/疾病預防的影響。內容包括;血栓調節、血管粥瘤硬化、周邊循環障礙、自律神經活性調節、心臟動力學特性、血管新生、紅血球流變學特性、發炎、免疫、細胞凋亡、癌症轉移與凝血等議題。

8.        研究成果先後發表於知名國際學術協會之 [指標性官方期刊] 六十餘篇。獲刊登期刊如下例:

[美國心臟協會]: Circulation, Arterioscler Thromb Vasc Biol, Stroke

[國際血栓暨凝血協會] : J Thromb Haemost, Thromb Haemost

[美國風濕免疫協會] : Arthritis Rheum

[美國生理學協會]: Am J Physiol-Cell Ph, Lung Cell Mol, Heart Circ,Regul Integr Comp,J Appl Physiol

[美國老人醫學協會]: J Am Geriatr Soc

[美國運動醫學協會]: Med Sci Sports Exerc

[美國物理醫學暨復健協會]: Arch Phys Med Rehabil

9.        文獻查詢顯示,王鐘賢教授所發表論文被學術期刊引用已達500 餘次。而在運動對血栓調節之

相關國際性論文 (SCI) 總引用頻率中,更超過80%,為目前國際學術於此議題被引述最高者。

10.     曾獲[國際血栓暨凝血協會] [美國心臟協會] 所屬之期刊Thromb Haemost Arterioscler Thromb Vasc Biol•在EDITORIAL FOCUS 中,就本實驗過去相關論文做 [專文論述] Exercise and the Prothrombotic State: A Paradox of Cardiovascular Prevention or an Enhanced Prothrombotic State? Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25: 265 266; Acute versus habitual exercise, thrombogenesis and exercise intensity. Thrombosis and Haemostasis 2004; 91: 416-419,並 刊登至 [期刊封面] 展示。

11.     論文成果已為復健醫學、運動科學等相關教科書 (Rehabilitation medicine: principles and practice) 收錄。

12.     受邀撰寫國際學術專書Physiology and Pathophysiology of Intermittent Hypoxia (Nova Science Publishers, Inc. (Hauppauge, New York 11788, U.S.A.)

13.     研究成果獲登載於英國出版之醫學百科全書 “Exercise and haemostasis in health and disease" on Medical Encyclopaedia 2009 出版

14.     國家科學會委員會獎勵特殊優秀人才: [ A] 獎勵

 

重要研究發現

※ 運動處方與健康促進/疾病預防

A. 血栓調節

1.        急性運動的強度是影響健康人或穩定性心絞痛病患之血栓形成的重要因素;亦即劇烈運動會促進血小板活性與其膜上黏著分子的表現,但中度運動反而會抑制血小板活性。

2.        規律的長期中度運動訓練能降低休息時期血小板活性及劇烈運動促進血小板活性的反應,但停止訓練後又會恢復至訓練前狀態。並且此一效應可能藉由一氧化氮釋放量改變而調節之。

B. 血管粥瘤硬化

1. 經由規律適度的運動訓練能提升體內抗氧化物質的含量,並降低低密度脂蛋白被氧化的程度及體內過氧化物質的含量,進而減緩過氧化刺激對血小板活化的程度。

2. 不同的運動劑量會影響氧化低密度脂蛋白趨化單核球遷移至血管內皮細胞下之能力,此機制與單核球上黏著分子的表現有關。

C. 周邊循環障礙

1.        規律的長期中度運動訓練能促進皮膚微循環之控制能力,並且此一效應可能藉由皮膚血管內皮細胞釋放一氧化氮含量改變而調節之。

2.        經太極拳訓練之老年人有較佳之皮膚血流與體溫調控的能力,並且此一效應可能藉由皮膚血管內皮細胞釋放一氧化氮含量改變而調節之。並且亦可減緩心肺適能與靜脈及動脈功能因老化而下降的程度。

3.        中風造成之癱瘓的上肢伴隨有內皮細胞控制血管功能的障礙,並且此現象可能與肢體水腫病程的發展有關。如以神經肌肉電刺激(NMES)造成肌肉收縮,引發肌肉唧筒作用,促進血液流動,可維持中風後血管內皮細胞機能,進而改善中風患者癱瘓上肢血管控制障礙的問題。

D. 發炎、免疫、細胞凋亡

1. 不同運動劑量可藉改變相異之分子機制的表現,以影響嗜中性白血球在黏著血小板界面之相互作用,進而調控急性損傷時之發炎反應程度。

2. 劇烈運動會促使淋巴球細胞內氧化還原態異常,加速細胞凋亡的速率,進而壓抑免疫功能的表現,增加感染機率。然而,對中度運動則否。

3. 緩和運動能壓抑劇烈運動促進之嗜伊紅性白血球與血小板凝集、血小板誘發嗜伊紅性白血球自由基的產生、與黏著分子的表現。

E. 癌症轉移與凝血

1. 先以中度緩和運動介入再進行較劇烈的運動可有效降低血小板與鼻咽癌細胞的相互凝集與後續引發的血液凝固反應。

2. 先以中度緩和運動介入再進行較劇烈的運動可有效增加自然殺手細胞數目、毒殺激素激素與細胞黏著分子的表現,促使提升自然殺手細胞毒殺鼻咽癌細胞效益。並且可同時防止血小板干擾自然殺手細胞毒殺鼻咽癌細胞的壞處。

3. 劇烈運動會促進血小板誘發鼻咽癌細胞滲入血管內皮細胞障壁下,加速癌細胞轉移的危險;但中度運動則否。

※ 低氧介入與健康促進/疾病預防

A. 體適能增進

給予受測者12%15%的氧氣、每天1小時、每週5天、為期48週後,皆會提升其無氧閥值與最大攝氧量,但不會明顯提升最大作功量。然而,如低氧合併中等強度(50%VO2max)的運動訓練,其攝氧量與作功量皆明顯增加,且其上升程度較單獨低氧或運動訓練來得高。

B. 自律神經活性調節

於不同低氧環境下,進行姿勢轉換及努責運動(Valsalva maneuver, 憋氣用力之活動) 時,對於自主神經有不同之反應。當處於12%的氧氣環境時,會鈍化上述物理性刺激所造成自主神經改變的程度,但於15%的氧氣環境則否。

C. 心臟收縮力與其作功效能

12%的氧氣環境下進行急性運動(一次50%VO2max強度運動),會降低心擊出量。但如以15%的氧氣環境進行運動訓練(50%VO2max)五週,則可化解12%的低氣運動對心臟收縮的壓抑性。

D. 骨骼肌的血流量與其組織利用氧氣的效益

15%的氧氣環境進行運動訓練(50%VO2max)五週後,可提升於常氧(21%)與劇烈低氣(12%)下,運動時血液流經骨骼肌的總量及其組織利用氧氣的效益。

E. 血管內皮前驅細胞(幹細胞)徵召與血管新生作用

15%的氧氣環境進行運動訓練(50%VO2max)五週後,可提升於劇烈低氣(12%)下,運動徵召血管內皮前驅細胞的能力,且使其分化成熟為具有功能性的血管內皮細胞,促進血管新生作用。

F. 紅血球形變能力與凝集程度

15%的氧氣環境進行運動訓練(50%VO2max)五週後,可化解於劇烈低氣(12%)下運動引發紅血球硬化與易凝集性之程度,此可能改善血液黏度與運送氧氣的的效益。

G. 血管張力與血栓發炎反應

 12%氧氣的間歇性低氧介入會造成血管阻力上升,進而引發運動時血壓偏高的現象,而其可能機制為增加氧化壓力、降低抗氧化能力,使致一氧化氮的生物活性下降,進而減弱其內皮細胞依賴性血管舒張反應。此外,此介入也會上升血栓與發炎相關危險因子表現。

 相對地,15% 氧氣的間歇性低氧介入,則對血管張力、血栓與發炎調節較無負面影響。因此,15% 氧氣的間歇性低氧介入,不僅能改善在次大強度下的有氧適能,亦較不會引發心血管相關之功能障礙。

H. 血管粥狀硬化病程

15%的氧氣環境進行運動訓練(50%VO2max)五週後,可化解於劇烈低氣(12%)下運動促進氧化低密度脂蛋白活化單核球產生凝血脢之表現,以降低其血管粥狀化進程中血栓形成的危險。

I. 先天性免疫與適應性免疫

中度運動合併12%15%氧氣濃度介入,可以向上調節黏著分子的表現,增強嗜中性白血球對大腸桿菌之吞噬及氧爆作用;後續亦會加速磷脂絲胺酸膜外翻,進而被巨噬細胞所辨識而將之吞入清除。

   激烈運動與12%氧氣濃度合併中度運動,雖然會暫時增加淋巴球在血液中的含量,不過隨之而來的是淋巴球缺少的現象,而且較不能抵抗氧化壓力;相對的15%氧氣濃度合併中度運動並不會造成運動恢復期免疫空窗的後遺症。

J. 毒殺癌細胞作用

           15%氧氣濃度合併中度運動可有效增加自然殺手細胞數目與其毒殺激素和黏著分子的表現,促使自然殺手細胞與鼻咽癌細胞接觸增多,並有效趨使鼻咽癌細胞走向凋亡。

 

Publication 

 

A.    期刊論文發表

2009-2014論文發表】

1.    Wang JS*, Cheng ML, Yen HC, Lou BS, Liu HC. Vitamin E suppresses the enhancement of factor VIII-dependent thrombin generation by systemic hypoxia. Stroke. 2009;40(2):656-9. (IF=5.729)(8/67)SCI

2.    Wang JS*, Chung Y, Chow SE. Exercise paradoxically modulates platelet-impeded apoptosis of nasopharyngeal carcinoma by natural killer cell. Med Sci Sports Exerc 2009; 41:115-122. (IF=4.431)(3/84)SCI

3.    Chen YW, Wang JS*. Exercise affects platelet-promoted tumor cell adhesion and invasion to endothelium. Eur J Appl Physiol 2009;105:393-401. (IF=2.147)(18/82)SCI

4.    Huang S-C, Wong M-K, Wang JS*. Systemic hypoxia affects cardiac autonomic activity and vascular hemodynamic control modulated by physical stimulation Eur J Appl Physiol 2009;106:31-40. (IF=2.147)(18/82)SCI

5.    Wang JS*, Liu Huang. Systemic hypoxia enhances bactericidal activities of human polymorphonuclear leukocytes. Clin Sci 2009;116:805-817. (IF=4.613)(17/106­)SCI

6.    Wang JS*, Chiu YT. Systemic hypoxia enhances exercise-mediated bactericidal and subsequent apoptotic responses in human neutrophils. J Appl Physiol. 2009;107(4):1213-22 (IF=4.235)(2/80)SCI

7.  Wang JS*, Wu CK.  Systemic hypoxia affects exercise-mediated antitumor cytotoxicity of natural killer cells. J Appl Physiol. 2009;107(6):1817-24. (IF=4.235)(2/80)SCI

8.  Wang JS*, Lin CT. Systemic hypoxia promotes lymphocyte apoptosis induced by oxidative stress during moderate exercise. Eur J Appl Physiol. 2010;108(2):371-82. (IF=2.147)(18/82)SCI

9.    Luo SF, Fang YY, Hsieh HL, Chi PL, Lin CC, Hsiao LD, Wu CC Wang JS, Yang CM. Involvement of MAPKs and NF{B in Tumor necrosis factor a-induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 2010;62(1):105-16. (IF=7.866)(3/29)SCI

10. Liu LN, Miaskowski C, Wang JS, Chen SC, Chen ML. Accuracy of body mass index to determine obesity in women with breast cancer: an observational study of Taiwanese sample. Int J Nurs Stud. 2010;47(8):994-1000. (IF=2.178)(3/97)SCI

11. Wang JS*, Wu MH, Mao TY, Fu TC, Hsu CC. Effects of normoxic and hypoxic exercise regimens on cardiac, muscular, and cerebral hemodynamics suppressed by severe hypoxia in humans. J Appl Physiol. 2010;109(1):219-29. (IF=4.235)(2/80)SCI

12. Hsu CC, Tsai WC, Chen CP, Lu YM, Wang JS*. Effects of negative pressures on epithelial tight junctions and migration in wound healing. Am J Physiol Cell Physiol. 2010;299(2):C528-34. (IF=3.536) SCI

13. Chen YW, Chen JK, Wang JS*. Strenuous exercise promotes shear-induced thrombin generation by increasing the shedding of procoagulant microparticles from platelets. Thromb Haemost. 2010;104(2):293-301. (IF=5.044)(19/79)SCI

14. Wang JS*, Chen WL, Weng TP. Hypoxic exercise training reduces senescent T-lymphocyte subsets in blood. Brain Behav Immun. 2011;25(2):270-8. (IF=4.720)(14/78)SCI

15. Chow SE, Chang YL, Chuang SF, Wang JS. Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63. Cancer Chemother Pharmacol. 2011;68(4):835-45. (IF=2.833)(92/261) SCI

16. Fu TC, Wang CH, Hsu CC, Cherng WJ, Huang SC, Wang JS*. Suppression of cerebral hemodynamics is associated with reduced functional capacity in patients with heart failure. Am J Physiol Heart Circ Physiol. 2011;300(4):H1545-55. (IF=3.881)(14/78)SCI

17. Mao TY, Fu LL, Wang JS*. Hypoxic exercise training causes erythrocyte senescence and rheological dysfunction by depressed Gardos channel activity. J Appl Physiol. 2011;111(2):382-91. (IF=4.235)(2/80)SCI

18. Wang JS*, Weng TP. Hypoxic exercise training promotes antitumour cytotoxicity of natural killer cells in young men. Clin Sci (Lond). 2011;121(8):343-53. (IF=4.613)(17/106­)SCI

19. Chow SE, Wang JS, Lin MR, Lee CL. Downregulation of p57kip² promotes cell invasion via LIMK/cofilin pathway in human nasopharyngeal carcinoma cells. J Cell Biochem. 2011;112(11):3459-68. (IF=2.868)(156/289­)SCI

20. Wang CH, Hsieh IC, Chen SJ, Wang JS, Cherng WJ, Chen CC, Lam IJ, Lin SJ. VE-Cadherin(low)α-Smooth Muscle Actin(+) Component of Vascular Progenitor Cells Correlates With the Coronary Artery Gensini Score. Circ J. 2012;76(2):477-84. (IF=3.766)(25/117­) SCI

21. Chen SW, Yang JM, Yang JH, Yang SJ, Wang JS. A computational modeling and analysis in cell biological dynamics using electric cell-substrate impedance sensing (ECIS). Biosens Bioelectron. 2012; 33:196-203 (IF=5.397) (1/26) SCI

22. Chow SE, Chen YW, Liang CA, Huang YK, Wang JS. Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. J Cell Biochem. 2012;113:3476-85. (IF=2.868)(156/289­)SCI

23. Liu MH, Wang CH, Huang YY, Tung TH, Lee CM, Yang NI, Wang JS, Kuo LT, Cherng WJ. Edema index-guided disease management improves 6-month outcomes of patients with acute heart failure. Int Heart J. 2012;53(1):11-7. (IF=1.116)(90/117) SCI

24. Lee MF, Chen WS, Fu TC, Liu MH, Wang JS, Hsu CC, Huang YY, Cherng WJ, Wang CH. Non-invasive cardiac index monitoring during cardiopulmonary functional testing provides additional prognostic value in patients after acute heart failure. Int Heart J. 2012;53(6):364-9. (IF=1.116)(90/117) SCI

25. Chen YW, Wang JS*. Intermittent hypoxia: Cause of or therapy for metabolic syndrome induced by obstructive sleep apnea. FJPT 2012;37: 126-135.

26. Huang SC, Wong AMK, Tang FT, Fu TC, Wang JS*. Systemic vascular resistance is increased and associated with accelerated arterial stiffening changes in patients with chronic spinal cord injury. Eur J Phys Rehabil. 2013 Feb;49(1):41-9. (IF=2.06)(29/58­)SCI

27. Lee IT, Lin CC, Wang CH, Cherng WJ, Wang JS, Yang CM. ATP stimulates PGE(2)/cyclin D1-dependent VSMCs proliferation via STAT3 activation: role of PKCs-dependent NADPH oxidase/ROS generation. Biochem Pharmacol. 2013 Apr 1;85(7):954-64. (IF=4.576)(29/260) SCI

28. Chen YW, Chen IJ, Wang JS*. Absolute hypoxic exercise training increases thrombin generation by enhancing procoagulant platelet-derived microparticles under high shear flow in sedentary men. Clin Sci (Lond). 2013 May;124(10):639-49. (IF=4.859)(17/121)SCI

29. Hsu CC, Chow SE, Chen CP, Tsai WC, Wang JS, Yu SY, Lee SC. Negative pressure accelerated monolayer keratinocyte healing involves Cdc42 mediated cell podia formation. J Dermatol Sci. 2013 Jun;70(3):196-203. (IF=3.520)(7/58) SCI

30. Fu TC, Wang CH, Lin PS, Hsu CC, Cherng WJ, Huang SC, Liu MH, Chiang CL, Wang JS*. Aerobic interval training improves oxygen uptake efficiency by enhancing cerebral and muscular hemodynamics in patients with heart failure. Int J Cardiol. 2013 Jul 15;167(1):41-50. (IF=7.078) (7/117)SCI

31. Wang JS*, Fu TC, Wang CH, Chou SL, Liu MH, Cherng WJ. Exertional periodic breathing potentiates erythrocyte rheological dysfunction by elevating pro-inflammatory status in patients with anemic heart failure. Int J Cardiol. 2013 Aug 20;167(4):1289-97. (IF=7.078) (7/117)SCI

32. Wang JS*. Anemia, heart failure and exercise training. Int J Cardiol. 2013 Sep 30;168(2):1525-6. (IF=7.078) (7/117)SCI

33. Wang JS*, Fu TC, Lien HY, Wang CH, Hsu CC, Wu WC, Chien YW, Cherng WJ. Effect of aerobic interval training on erythrocyte rheological and hemodynamic functions in heart failure patients with anemia. Int J Cardiol. 2013 Sep 30;168(2):1243-50. (IF=7.078) (7/117)SCI

34. Chen YW, Chen YC, Fu TC, Wang CH, Huang SC, Wang JS*. Anemic comorbidity reduces capacity of endogenous thrombin generation and is associated with consumptive coagulopathy in patients with heart failure. Int J Cardiol. 2013 Oct 12;168(5):4965-7. (IF=7.078) (7/117)

35. Weng TP, Huang SC, Chuang YF, Wang JS*. Effects of interval and continuous exercise training on CD4 lymphocyte apoptotic and autophagic responses to hypoxic stress in sedentary men. PLoS One. 2013 Nov 13;8(11):e80248. (IF= 3.73)SCI

36. Chen YC, Lin SP, Shen PT, Wang JS*. Comparisons of materials of clothing on physiological thermoregulation during walking. Taiwan Textile Research Journal. 2013;23:19-28

37. Huang SC, Wong AM, Chuang YF, Liu YC, Tsai WL, Wang JS*. Effects of neuromuscular electrical stimulation on arterial hemodynamic properties and body composition in paretic upper extremities of patients with subacute stroke. Biomed J. 2014 Jul-Aug;37(4):205-10.

38. Mao CT, Liu MH, Hsu KH, Fu TC, Wang JS, Huang YY, Yang NI, Wang CH. Effect of multidisciplinary disease management for hospitalized heart failure under a national health insurance programme. J Cardiovasc Med (Hagerstown). 2014 Aug 7. [Epub ahead of print] (IF=2.657)SCI

39. Huang SC, Wong MK, Lin PJ, Tsai FC, Fu TC, Wen MS, Kuo CT, Wang JS*. Modified high-intensity interval training increases peak cardiac power output in patients with heart failure. Eur J Appl Physiol. 2014 Sep;114(9):1853-62. (IF=2.660)SCI

40. Weng TP, Fu TC, Wang CH, Hsu CC, Wang JS*. Activation of lymphocyte autophagy/apoptosis reflects haemodynamic inefficiency and functional aerobic impairment in patients with heart failure. Clin Sci (Lond). 2014 Nov;127(10):589-602. (IF=4.859)SCI

41. Lou BS, Wu PS, Liu Y, Wang JS. Effects of acute systematic hypoxia on human urinary metabolites using LC-MS-based metabolomics. High Alt Med Biol. 2014 Jun;15(2):192-202. (IF=2.122)SCI

42. Liu LN, Wen FH, Miaskowski C, Lin YC, Wang JS, Jeng C, Chen ML. Weight change trajectory in women with breast cancer receiving chemotherapy and the effect of different regimens. J Clin Nurs. 2014 Jan 7. (IF=1.316)SCI

43. Wang JS*, Lee MY, Lien HY, Weng TP. Hypoxic exercise training improves cardiac/muscular hemodynamics and is associated with modulated circulating progenitor cells in sedentary men. Int J Cardiol. 2014 Jan 1;170(3):315-23. (IF=5.509)SCI

44. Chow SE, Kao CH, Liu YT, Cheng ML, Yang YW, Huang YK, Hsu CC, Wang JS. Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells. Apoptosis. 2014 Mar;19(3):527-41. (IF=3.949)SCI

45. Fu TC, Huang SC, Wang JS*. Cardiac rehabilitation in patients with heart failure. Acta Cardiologica Sinica. 2014, [Epub ahead of print] (IF=0.667)SCI

46. Huang SC, Wong MK, Ho CW, Weng TP, Cheng SC, Wang JS*. Effects of menstrual cycle on disturbance of cardiac autonomic nervous system caused by sleep deprivation. Chin J Physiol. 2014, Jun 1. [Epub ahead of print] (IF=0.748)SCI

47. Wang JS*, Chang YL, Chen YC. Moderate Hypoxic Exercise training suppresses monocyte-mediated thrombin generation by decreasing formation of procoagulant microparticles under severe hypoxic stress Int J Cardiol. 2014, submitted.

48. Chen YC, Ho CW, Tsai HH, Wang JS*. Interval and continuous exercise regimens suppress neutrophil-derived microparticle formation and neutrophil-promoted thrombin generation under hypoxic stress. Clin Sci. 2014, submitted.

49. Fu TC, Wang CH, Huang SC, Hsu CC, Wang JS*. Aerobic interval training elicits different hemodynamic adaptations between heart failure patients with preserved and reduced ejection fraction. Am J Cardiol. 2014, submitted.

50. Fu TC, Wang CH, Huang SC, Hsu CC, Wang JS*. The novel classification of ventilation response to exercise in patients with heart failure - Determination of oscillatory patterns by automated computer analysis. Am J Cardiol. 2014, submitted.

51. Huang SC, Wong MK, Ho CW, Weng TP, Cheng SC, Wang JS*. Passive leg raising predicts exercise intolerance after coronary revascularization. J Thorac Cardiovasc Surg. 2014, submitted.

52. Mao TY, Fu LL, Wang JS*. Reliability and validity of determining ventilatory threshold and respiratory compensationpoint by near-infrared spectroscopy. High Alt Med Biol. 2014, submitted.

53. Mao TY, Fu LL, Wang JS*. Hypoxic Exercise Training Causes Opposite Hyperventilatory Effects on Cerebral Hemodynamics and Blood Acidosis Defense. High Alt Med Biol. 2014, submitted.

54. Chen SW, Yang JM, Yang JH, Hsu CC, Wang JS. A Quantitative Modeling and Wound-Healing Analysis of HaCaT Cells with the Electric Cell-substrate Impedance Sensing (ECIS) Method. Biosens Bioelectron. 2014, submitted.

55. Hsu CC, Chen PC, Shu-Er Chow SE, Tsai WC, Wang JS, Chen CH, Hsu NC, Lo YK. Hypobaric pressure accelerated collective cell migration by altering cell-cell Junctions and Membrane Morphologies. J Cell Sci. 2014, submitted.

56. Hsu CC, Huang SF, Wang JS, Liu YTA, Lee CL, Nien JE, Chen WS, Liao YY, Chow SE. Positive Auto-regulation of MMP-9 Enhanced Carcinoma Cell Invasion via Triggering Shedding of N-cadherin. Mole Cancer. 2014, submitted.

57. Chen YW, Lip GYH, Fisher JP, Wang JS, Aldred S, Blann AD. Hemostatic and fibrinolytic responses to low volume high intensity interval and steady-state exercise in humans. Thromb Res. 2014, submitted.

1994-2008論文發表】

58. Wang JS, Jen CJ, Kung HC, Lin LJ, Hsiue TR, Chen HI. Different effects of strenuous exercise and moderate exercise on platelet function in men. Circulation. 1994;90:2877-85. SCI

59. Wang JS, Jen CJ, Chen HI. Effects of exercise training and deconditioning on platelet function in men. Arteriosclero Thromb Vasc Biol. 1995;15:1668-74.SCI

60. Jen CJ, Li HM, Wang JS, Chen HI. Usami S. Flow-induced detachment of adherent platelets from fibrinogen-coated surface. Am J Physiol. 1996;270(1 Pt 2):H160-6. SCI

61. Wang JS, Jen CJ, Lee H, Chen HI. Effects of short-term exercise on female platelet function during different phases of the menstrual cycle. Arteriosclero Thromb Vasc Biol. 1997;17(9):1682-6. SCI

62. Wang JS, Jen CJ, Chen HI. Effects of chronic exercise and deconditioning on platelet function in women. J Appl Physiol. 1997;83:2080-5. SCI

63. Shen AY, Huang MH, Teng C-M, Wang JS*. Inhibition of 2-P-mercaptophenyl- 1,4-naphthoquinone on human platelet function. Life Sci. 1999; 65:45-53. SCI

64. Wang JS*, Cheng L-J. The effect of strenuous acute exercise on 2-adrenergic agonist-potentiated platelet activation. Arteriosclero Thromb Vasc Biol. 1999;19:1559-65. SCI

65. Shen A-Y, Teng C-M, Wang JS. Studies on the cardiovascular action of TPY-b: an antihypertensive agent with antoplatelet activity. Life Sci. 1999; 65:1817-28. SCI)

66. Wang JS*, Lin C-C, Chen J-K, Wong M-K. Role of Chronic exercise in decreasing oxidized LDL-potentiated platelet activation by enhancing platelet-derived NO release and bioactivity in rats. Life Sci. 2000;66:1937-48.SCI

67. Wang JS*, Chow S-E, Chen J-K, Wong M-K. Effect of exercise training on oxidized LDL-mediated platelet function in rats. Thromb Haemost. 2000;83;503-508. SCI

68. Chow S-E, Wang JS, Li K-C, Shik SH.  Oxidized LDL exposure induces morphological change independent of Rac and Ras expression but may involve intracellular Ca2+ in vascular endothelial cells.  Biol Bull NTNU. 1999:34(1):15-24.

69. Chen J-H, Chen H-I , Wang JS, Tsai S-J, Jen C-J . Effects of welsh onion extracts on human platelet function in vitro. Life Sci. 2000;66:1571-9. SCI

70. Wang JS*, Yang CF, Wong M-K, Chow S-E, Chen J-K.  Effect of strenuous arm exercise on oxidized-LDL-potentiated platelet activation in individuals with spinal cord injury. Thromb Haemost. 2000;84:118-23.SCI

71. Wang JS*, Lin PS, Wong M-K. Effects of Tai Chi Chuan on cutaneous microcirculatory and cardiorespiratory function in elderly men. Formos J Phys Ther. 2000; 25:126-133.

72. Wang JS*. Exercise dosage and thrombotic modification: Benefits and risks associated with exercise in cardiovascular disease. Formos J Physic Ther. 2000;25:269-277.

73. Wang JS*, Lan C, Wong M-K.  Tai Chi Chuan to enhance microcirculatory function in health elderly men. Arch Phys Med Rehabil. 2001;82:1176-1180.SCI

74. Wang JS*. Exercise and Platelet. Life Science News Letter. 2001;15:1-6.

75. Wang JS*. Circulation and Tai Chi Training. Clinical Pearls. 2002; 156.

76. Wang JS*, Yang CF, Liaw MY, Wong MK. Suppressed cutaneous endothelial vascular control and hemodynamic changes in paretic extremities with edema in the extremities of patients with hemiplegia. Arch Phys Med Rehabil. 2002: 83;1017-1023.SCI

77. Wang JS*, Yang CF, Wong M-K.  Effect of strenuous, arm exercise on platelet function in patients with spinal cord injury. Arch Phys Med Rehabil. 2002: 83;210-216. SCI

78. Wang JS*, Lan C, Chen S-Y, MD, Wong M-K. Tai Chi Chuan Training is associated with enhanced endothelium-dependent dilation in skin vasculature of healthy elderly men. J Am Geriatr Soc. 2002; 50:1024-1030. SCI

79. Wang JS*, Chow SE, PhD, Chen J-K. Strenuous , acute exercise affects reciprocal modulation of platelet and polymorphonuclear leukocyte activities under shear flow in men J Thromb Haemost. 2003;1: 2031-7. SCI

80. Wang JS*, Liao CH. Moderate-intensity exercise suppresses platelet activation and polymorphonuclear leukocytes interaction with surface-adherentplatelets under shear flow in men Thromb Haemost. 2004; 91;587-94 SCI

81. Wang JS*. Intense exercise increases shear-induced platelet aggregation through enhancement of von Willebrand factor Binding ,glycoprotein IIb/IIIa activation and P-selectin expression. Eur J Appl Physiol. 2004;91:741-7SCI

82. Wang JS*, Chen SY, Lan C, Wong MK, Lai JS. Neuromuscular electrical stimulation enhances endothelial vascular control and hemodynamic function in paretic upper extremities of patients with stroke. Arch Phys Med Rehabil. 2004; 85:1112-6.SCI

83. Wang JS*, Shu-Er Chow. Effects of exercise training and detraining on oxidized LDL-mediated platelet function in men.  Arch Phys Med Rehabil. 2004; 85: 1531-7. SCI

84. Wang CC, Lin WN, Lee CW, Lin CC, Luo SF, Wang JS, Yang CM. Involvement of p42/p44 MAPK, p38 MAPK, JNK and NF-描述: 描述: {kappa}B in Interleukin-1描述: 描述: {beta}-induced VCAM-1 Expression in Human Tracheal Smooth Muscle Cells. Am J Physiol. 2004; 288:L227-37. SCI

85. Wang JS*. Effects of physical conditioning and drugs on circulatory function in the elderly The Journal of Long-term Care. 2004;8(4):398-407.

86. Wang JS*. Effects of Exercise Training and detraining on cutaneous microvascular function in Men: The regulatory role of endothelium-dependent dilation in skin vasculature Eur J Appl Physiol. 2005;93: 429-34SCI

87. Wang JS*. Strenuous, acute exercise suppresses polymorphonuclear leukocyte respiratory burst under adherence to surface-adherent platelets in men. Thromb Haemost. 2005; 92:1076-1085SCI

88. Wang JS*, Li Y-S, Chen J-C. Effects of exercise training and deconditioning on platelet Aggregation induced by alternating shear stress in men. Arteriosclero Thromb Vasc Biol. 2005;25:454-460SCI

89. Wang JS*, Chen Y-W, Chow S-E. Exercise paradoxically modulates oxidized LDL-induced adhesion molecules expression and trans-endothelial migration of monocyte in men. Thromb Haemost. 2005; 94;846-52SCI

90. Wang JS*, Huang Y-H. Effects of exercise intensity on lymphocyte redox status and apoptosis induced by oxidative stress in men. Eur J Appl Physiol. 2005; 95;290-297SCI

91. Lee CW, Lin WN, Lin CC, Luo SF, Wang JS, Pouyssegur J, Yang CM. Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-a in human tracheal smooth muscle: involvement of MAPKs, NF-kB, p300, and histone acetylation. J Cell Physiol 2006;288:L227-37SCI

92. Wang JS*, Yen HL, Yang CM, Warm-up exercise suppresses platelet-eosinophil aggregation and platelet-promoted release of eosinophil oxidant products enhanced by severe exercise under shear flow and inflammation in men Thromb Haemost. 2006;207:174-86. SCI

93. Wang JS*, Lee T, Chow SE. Effects of exercise intensities on oxidized-low density lipoprotein-mediated redox status of monocyte in men. J Appl Physiol. 2006; 101:740-744SCI

94. Wang JS*. Exercise prescription and thrombogenesis. J Biomed Sci. 2006: 2006;13:753-761. SCI

95. S-E Chow, Wang JS, J-K Chen. trans-Resvertrol blocks the early atherogenic events elicited by oxidized low density lipoprotein in cultured endothelial cells. Chin J Physiol. 2007; 28;50:22-8. (IF=0.588)(71/79)SCI

96. Chow SE, Hshu YC, Wang JS, Chen JK. Resveratrol Attenuates OxLDL-stimulated NADPH Oxidase Activity and Protects Endothelial Cells from Oxidative Functional Damages. J Appl Physiol. 2007: 102;1520-1527. (IF=4.235)(2/80)SCI

97. Wang JS*, Chen LY, Fu LL, Cheng ML, Wong MK. Effects of moderate and severe intermittent hypoxia on vascular endothelial function and haemodynamic control in sedentary men. Eur J Appl Physiol. 2007: 100;127-135. (IF=2.147)(18/82)SCI

98. Lin WN, Luo SF, Lee CW, Wang CC, Wang JS, Yang CM. Involvement of MAPKs and NF-kappaB in LPS-induced VCAM-1 expression in human tracheal smooth muscle cells. Cell Signal. 2007;19:1258-67. (IF=4.058)(67/180)SCI

99. Wang JS*, Chang CY, Chow SE, Chen YW, Yang CM. Exercise modulates platelet-nasopharyngeal carcinoma cell aggregation and subsequent tissue factor and matrix metalloproteinase activities. J Appl Physiol. 2007:103;763-770. (IF=4.235)(2/80)SCI

100.    Wang JS*, Lin HY, Cheng ML, Wong MK.Chronic intermittent hypoxia modulates eosinophil- and neutrophil-platelet aggregation and inflammatory cytokine secretion caused by strenuous exercise in men. J Appl Physiol. 2007: 103:305-14. (IF=4.235)(2/80)SCI

101.    Wang CH, Cherng WJ, Yang NI, Hsu CM, Yeh CH, Lan YJ, Wang JS, Verma S. Cyclosporine increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system. Am J Physiol- Regul Integr Comp Physiol. 2008; 294:R811-8. (IF=3.336)(21/79)SCI

B.    近五年專書明細

國際

1.        Physiology and Pathophysiology of Intermittent Hypoxia. Jong-Shyan Wang. Chapter 24: Effects of Intermittent Hypoxia Training on Human Cytokine Responses to ExerciseNova Science Publishers, Inc. (Hauppauge, New York 11788, U.S.A.; www.novapublishers.com ) 2009, in press

2.        High Altitude Medicine and Physiology, Jong-Shyan Wang. From Chapter 4 to Chapter 9 Translation; Hodder Arnold, 2009 in press

 

國內

1.        實用解剖• 2008•華格那出板社

2.        實用生理學•2008•華格那出板社

3.        運動生理學•2008•新文京出板社

4.        循環與呼吸物理治療學•2009•華格那出板社

5.        運動生理學•2009•華格那出板社

 

C.    產學合作專利(2011~)

1.   復健指引方法與復健指引系統

2.        個人化心電圖辨識回饋方法與系統

3.        智能互動腳踏車方法與系統