謝宗勳助理教授

 

聯絡資訊

 

Tel: 886-3-211-8800 ext 3860

mailhsiehth@mail.cgu.edu.tw 

 

主要學歷

 

國立成功大學生物醫學工程研究所博士
長庚大學復健科學研究所所碩士
中國醫藥大學物理治療系學士

 

專長領域

 

系統神經科學、生物電生理、神經工程、生醫訊號處理、動物行為科學

 

Recent Publication

 

A.      期刊論文 (*共同第一作者, † 相同貢獻作者)

 

 1.Hsieh TH, Huang YZ, Rotenberg A, Pascual-Leone A, Chiang YH, Wang JY, Chen JJ. Functional dopaminergic neurons in substantia nigra are required for transcranial magnetic stimulation induced motor plasticity. Cerebral Cortex. 25(7):1806-14,   

2015.

2. Hsieh TH, Huang YZ, Chen JJJ, Rotenberg A, Chiang YH, Chang Chien WS, Chang V, Wang JY, Peng CW. Novel use of theta burst cortical electrical stimulation for modulating motor plasticity in rats. Journal of Medical and Biological Engineering, 2015. 35(1): 62-68.

3. Lin YT#, Hsieh TH#(#Co-first Author), Chen SC, Lai CH, Kuo TS, Chen CP, Lin CW, Young ST, Peng CW. Effects of pudendal neuromodulation on bladder function in chronic spinal cord-injured rats. J Formos Med Assoc, doi: 10.1016/j.jfma.2015.07.010.

4. Lee HY#, Hsieh TH# (#Co-first Author), Liang JI, Yeh ML, Chen JJ. Quantitative video-based gait pattern analysis for hemiparkinsonian rats. Medical & Biological Engineering & Computing, 50(9):937-946, 2012.

5. Hsieh TH, Dhamne SC, Chen JJ, Carpenter LL, Anastasio EM, Pascual-Leone A, Rotenberg A. Minimal heating of aneurysm clips during repetitive transcranial magnetic stimulation. Clinical Neurophysiology, 123(7):1471-1473, 2012.

6. Hsieh TH, Dhamne SC, Chen JJ, Pascual-Leone A, Jensen FE, Rotenberg A. A new measure of cortical inhibition by mechanomyography and paired-pulse transcranial magnetic stimulation in unanesthetized rats. Journal of Neurophysiology, 107(3): 966-972, 2012.

7. Hsieh TH, Chen JJ, Chen LH, Chiang PT, Lee HY. Time-course gait analysis of hemiparkinsonian rats following 6-hydroxydopamine lesion. Behavioural Brain Research. 222(1):1-9, 2011.

8. Chang YJ#, Hsieh TH#(#Co-first Author), Huang YM, Hsu MJ, Wong AMK. A lack of modulation of motor evoked potential in sensory-impaired individuals with spinal cord injuries. Journal of Medical and Biological Engineering, 31(1): 37-43, 2011.

9. Hsieh TH, Tsai JY, Wu YN, Hwang IS, Chen TI, Chen JJ. Time course quantification of spastic hypertonia following spinal hemisection in rats. Neuroscience, 167(1): 185-198, 2010.

10. Yu YW, Hsieh TH, Chen KY, Wu CC, Hoffer BJ, Greig NH, Li Y, Lai JH, Chang F, Lin JW, Chen YH, Yang LY, Chiang YH (2016, Mar). Glucose-dependent nsulinotropic Polypeptide Ameliorates Mild Traumatic Brain Injury-induced ognitive and Sensorimotor Deficits and Neuroinflammation in Rats. Journal of Neurotrauma, doi:10.1089/neu.2015.4229. 2016. (In press)

11. Tsai EM, Wang YC, Lee TT, Tsai CF, Chen HS, Lai FJ, Yokoyama KK, Hsieh TH, Wu RM, Lee JN. (2015, Nov). Dynamic Trk and G Protein Signalings Regulate Dopaminergic Neurodifferentiation in Human Trophoblast Stem Cells. PLoS One, 10(11):e0143852..

12. Chen SC, Hsieh TH, Fan WJ, Lai CH, Chen CL, Wei WF, Peng CW. Design and evaluation of potentiometric principles for bladder volume monitoring: a preliminary study. Sensors. 15(6):12802-15, 2015.

13. Hameed MQ, Goodrich GS, Dhamne SC, Amandusson A, Hsieh TH, Mou D, Wang Y, Rotenberg A. A Rapid Lateral Fluid Percussion Injury (rLFPI) rodent model of traumatic brain injury and post-traumatic epilepsy. NeuroReport. 25(7): 532-536, 2014.

14. Dhamne SC, Kothare RS, Yu C, Hsieh TH, Anastasio EM, Pascual-Leone A, Rotenberg A. A measure of acoustic noise generated from transcranial magnetic stimulation coils. Brain Stimulation. 7(3): 432-434, 2014.

15. Fan WJ, Chen SC, Hsieh TH, Lai CH, Lin YS, Peng CW, Kou YR. Influence of Serotonergic Mechanisms on the Urine Flow Rate in Male Rats. Am J Physiol Regul Integr Comp Physiol. 307(10):R1239-1250, 2014.

16. Tsai YP, Chang CW, Lee JS, Liang JI, Hsieh TH, Yeh ML, Sze CI. Direct radiofrequency application improves pain and gait in collagenase-induced acute achilles tendon injury. Evidence-Based Complementary and Alternative Medicine. 2013:402692, 2013

17. Liang JI, Lin PC, Chen MY, Hsieh TH, Chen JJ, Yeh ML. The effect of tenocyte/hyaluronic acid therapy on the early recovery of healing Achilles tendon in rats. Journal of Materials Science: Materials in Medicine. 25(1):217-27, 2014.

18. Lin YT, Lai CH, Kuo TS, Chen CC, Chen YL, Young ST, Chen SH, Lai JS, Hsieh TH, Peng CW. Dual-channel neuromodulation of the pudendal nerve with a closed-Loop control strategy to improve bladder functions. Journal of Medical and Biological Engineering. 34(1): 82-89, 2014.

19. Liang JI, Chen MY, Hsieh TH, Liu CY, Lam CF, Chen JJ, Yeh ML. Video-based gait analysis for functional evaluation of healing achilles tendon in rats. Annals of Biomedical Engineering. 40(12):2532-2540, 2012.

20. Lee TT, Tsai CF, Hsieh TH, Chen JJ, Wang YC, Kao MC, Wu RM, Singh S, Tsai EM, Lee JN. Ectopic pregnancy-derived human trophoblastic stem cells regenerate dopaminergic nigrostriatal pathway to treat parkinsonian rats. PLoS ONE. 7(12): e52491, 2012.

21. Huang CY, Hsieh TH, Lu SC, Su FC. Effect of the kinesio tape to muscle activity and vertical jump performance in healthy inactive people. BioMedical Engineering Online, 10(1):70, 2011.

22. Leong MI,  Chang YJ, Hsieh TH*. Efficacy of Exercise Training on the Postural Control, Locomotor Function and Cardiorespiratory Endurance in Individuals with Traumatic Brain Injury: Systematic Review. Formosa Journal of Physical Therapy, 41(1):7-19, 2016.

 

.

B.研討會發表

1. Hsieh TH, Huang YZ, Rotenberg A, Chiang YH, Chen JJ. Early repetitive transcranial magnetic stimulation intervention exerts neuroprotective effects and ameliorates motor deficits on Parkinson's disease model of rats. Neuroscience 2015 (45th annual meeting of the Society for Neuroscience). Chicago, USA. 2015.

2. Wu YW, Chan SY, Chiang YH, Hsieh TH.  Quantitative Assessment between Mechanical Impact and Neurolocical Properties in Vivo Mouse Model of diffuse traumatic brain injury. Annual Symposium on Biomedical Engineering and Technology. Taipei, Taiwan, 2015.

3. Peng CW, Huang YZ, Chen JJ, Chiang YH, Chen SC, Hsieh TH*. Cortical Electrical Stimulation with Theta Burst Paradigm for the Neuroplastic Modulation in the Rat. The 2nd Bangkok International Conference on Biological Engineering & Natural Science, Bangkok, Thailand, Jan 18-20, 2014.

4. Hsieh TH, Peng CW, Huang YZ, Rotenberg A, Chen JJ, Wang JY, Chiang YH. Modulation of motor cortical excitability by theta burst cortical electrical stimulation in rats. Neuroscience 2013, San Diego, California, USA, Nov 9-13, 2013.

5. Lee H, Hsieh TH, Hameed MQ, Hensch T, Rotenberg A. Loss of parvalbumin interneurons underlies impaired cortical inhibition in post-traumatic epileptogenesis. Neuroscience 2013, San Diego, California, USA, Nov 9-13, 2013.

6. Hameed MQ, Hsieh TH, Morales-Quezada JL, Goodrich GS, Wang XH, Rosenberg P, Rotenberg A. Ceftriaxone treatment after traumatic brain injury preserves cortical inhibition and improves functional outcomes. Neuroscience 2013, San Diego, California, USA, Nov 9-13, 2013.

7. Hameed MQ, Hsieh TH, Morales-Quezada JL, Wang X, Zelener J, Rosenberg P, Rotenberg A. Ceftriaxone treatment of Traumatic Brain injury. Military Health System Research Symposium (MHSRS), Fort Lauderdale, Florida, USA, 12-15 Aug, 2013.

8. Kang JW, Hsieh TH, Yu YW, Chiang YH, Wang JY. Quantitative assessment of impact kinematics and injury severity in an experimental model of weight-drop induced traumatic brain injury. 2013 International Symposium on Physiomics & Taiwan-Hong Kong Physiology Symposium. Nov 1-2, 2013, Taipei, Taiwan

9. Chang Chien WS, Hsieh TH, Peng CW, Chen JJ. Novel Use of Theta Burst Cortical Electrical Stimulation for Modulating Brain Plasticity in Parkinsons Disease Rats. 2013 International Symposium on Physiomics & Taiwan-Hong Kong Physiology Symposium. Nov 1-2, 2013, Taipei, Taiwan

10. Hsieh TH, Huang YZ, Chen JJ. Magnitude of Dopamine Depletion Predicts Plasticity Deficits in a Rat Model of Parkinson's disease. 1st Taiwan International Congress of Parkinsons Disease and Movement Disorders (2013TIC), Taipei, Taiwan, Mar 30-31, 2013.

11. Hameed M, Hsieh TH, Goldie J, Rotenberg A. Paired-pulse transcranial magnetic stimulation as a feedback sensor in a closed loop analgesia/anesthesia system. Military Health System Research Symposium (MHSRS). Florida, USA. Aug 13-16, 2012.

12. Hsieh TH, Hameed M, Chen JJ, Wang YP, Amandusson A, Pascual-Leone A, Jensen FE, Rotenberg A. Progressive loss of intracortical inhibition following traumatic brain injury detected by transcranial magnetic stimulation and mechanomyogram in rats. American Epilepsy Society 65th Annual Meeting, Baltimore, USA. Abstr: 3.075, Dec 2-6, 2011.

13. Hsieh TH, Dhamne S, Pascual-Leone A, Jensen F, Rotenberg A. Loss of cortical inhibition following traumatic brain injury detected by mechanomyography and paired-pulse transcranial magnetic stimulation in unanesthetized rats. Advanced Technology Applications for Combat Casualty Care (ATACCC) 2011 Conference. Florida, USA, 15-18 August, 2011.

14. Hsieh TH, Dhamne S, Chen JJ, Pascual-Leone A, Jensen FE, Rotenberg A. Loss of cortical inhibition following traumatic brain injury detected by mechanomyography and paired-pulse transcranial magnetic stimulation in unanesthetized rats. European Congress on Clinical Neurophysiology and International Conference on Transcranial Magnetic and Direct Current Stimulation, Rome, Italy. Abstr P20.9, June 21-25, 2011.

15. Dhamne S, Hsieh TH, Carpenter L, Anastasio E, Pascual-Leone A, Rotenberg A. Minimal heating of aneurysm clips during repetitive transcranial magnetic stimulation. European Congress on Clinical Neurophysiology and International Conference on Transcranial Magnetic and Direct Current Stimulation, Rome, Italy. Abstr: P20.10, June 21-25, 2011.

16. Dhamne S, Ekstein D, Hsieh TH, Loddenkemper T, Pascual-Leone A, Jensen FE, Rotenberg A. Cathodal transcranial direct current stimulation suppresses pentylenetetrazol-induced seizures in rats. European Congress on Clinical Neurophysiology and International Conference on Transcranial Magnetic and Direct Current Stimulation, Rome, Italy. Abstr: P20.8, June 21-25, 2011.

17. Zhou Z, Dhamne SC, Hsieh TH, Ekstein D, Pascual-Leone A, Loddenkemper T, Jensen FE, Rotenberg A. Enhanced cortical inhibition accompanies seizure suppression by cathodal transcranial direct current stimulation in pentylenetetrazole rat seizure model. American Epilepsy Society 65th Annual Meeting, Baltimore, USA. Abstr: 3.073. Dec 2-6, 2011.

18. Hameed MQ, Goodrich GS, Dhamne SC, Hsieh TH, Wang YP, Rotenberg A. Rapid lateral fluid percussion injury (rLFPI): A model of traumatic brain injury and post-traumatic epilepsy. American Epilepsy Society 65th Annual Meeting, Baltimore, USA. Abstr: P20.10. Dec 2-6, 2011.

19. Liang JI, Liu CY, Hsieh TH, Chen JJJ, Chen MY, Yeh ML. Evaluation of function in the rat Achilles tendon repair. The IVth International Symposium and Workshop on Virtual Interactive Musculoskeletal System (VIMS), Tainan, Taiwan, Oct 28-29, 2010

20. iang PT, Lee HY, Hsieh TH, Liang JI. Time-course analysis of gait pattern following hemiparkinsonian in rats. 2009 International symposium on biomedical engineering combined with the annual scientific meeting of biomedical engineering society of R.O.C., Taipei, Dec 11-12, 2009.

21. Chen JJJ, Hsieh TH, Huang YZ. Biomechanical and Electrophysiological Analysis of Repetitive Transcranial Magnetic Stimulation Effect on Parkinsonian Rats. Asian Pacific Conference on Biomechanics, Christchurch, New Zealand, April 14-17, 2009.

22. Lee HY, Liu YW, Chang TC, Hsieh TH, Chen JJJ. Development of an Inexpensive Gait Pattern Analysis System for Parkinsonian Rats. Asian Pacific Conference on Biomechanics, Christchurch, New Zealand, April 14-17, 2009.

 

 

C.研究計畫明細

執行期間

計畫名稱

經費來源

擔任工作

2014~2016

發展皮質電刺激技術於增進帕金森大鼠之神經可塑性與運動功能之研究

(103-2320-B-038-056-MY2)

科技部

主持人

2014~2017

在腦損傷鼠模式下探討中樞神經電刺激調控對於膀胱功能之影響

(103-2221-E-038 -007 -MY3)

科技部

共同主持人

2015-2018

重複性經顱光電刺激調控運動神經可塑性改善帕金森氏症大鼠運動功能(104-2314-B-006 -007 -MY3)

科技部

共同主持人

2015-2016

發展神經退化性疾病之電生理生物指標以及相對應之治療策略:以亨丁頓舞蹈症為例--發展神經退化性疾病之電生理生物指標以及相對應之治療策略:以亨丁頓舞蹈症為例(104-2745-B-010 -002 -)

科技部

共同主持人

2015-2016

臺灣小鼠診所--國家綜合小鼠表現型暨藥效分析中心(104-2325-B-001 -011)

科技部

共同主持人

2015-2016

Netrin-1ephrin訊息的協同作用,對脊髓運動神經發育所扮演的角色(104-2311-B-038 -004)

科技部

共同主持人

2014-2015

微型化經顱直流電系統之研發與復健治療應用(第二年)

(103-2321-B-038 -013)

科技部

共同主持人

2014~2015

第五型趨化物對於神經退化中所扮演的角色(103-2314-B-038 -024)

科技部

共同主持人

2014~2015

運動及環境豐富化引發的神經滋養與神經重塑在輕度腦外傷動物的治療效果

(103-2314-B-038 -005)

科技部

共同主持人

2013-2014

微型化經顱直流電系統之研發與復健治療應用(102-2321-B-038 -008 )

科技部

共同主持人

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

D.研發成果專利

 

類別

專利名稱

國別

專利號碼

發明人

專利期間

A

動物行為監測方法

中華民國

I468967

梁仁溢謝宗勳、葉明龍

2009/07 2029/07

A

動物實驗步態存錄分析方法

中華民國

I386239

李筱瑜、張登慶、謝宗勳、程政群

 2012/03 2032/03

A

動物步態檢測系統與方法

中華民國

I484941

梁仁溢、謝宗勳

2012/05 2032/05

A

定量與產生腦創傷動物模式之方法與系統

中華民國

I493374

謝宗勳、康靜維、蔣永孝、王家儀、彭志維、尤郁雯

2015/07 2033/12

B

動物行爲量測裝置

中華民國

M504987

謝宗勳、陳凱筠、吳忠哲、蔣永孝

2015/07 2024/12

 

E. 榮譽及獎勵

 

1.2015 Journal of Medical and Biological Engineering 期刊年度 優秀論文

2.張簡宛珊,謝宗勳,彭志維,陳家進。2013生物醫學工程科技研討會-優等論文

3.謝宗勳,獲國科會補助出席國際會議: Neuroscience 2013, San Diego, USA, 2013

4.謝宗勳指導國科會候鳥計畫(Taiwan Tech Trek)學員Vincent Chang獲得2013候鳥計畫-成果發表會-生命科學組-第二名

5.謝宗勳,榮獲中華民國斐陶斐榮譽學會 (The Phi Tau Phi Scholastic Honor Society)榮譽會員,2012

6.謝宗勳,獲國科會赴海外研究計畫補助前往哈佛大學醫學院神經科研究,NSC98-2917-I-006-113 (2010/06-2011/06)

7.謝宗勳、李志明、謝尚衡、張登慶,可攜式吞嚥量測治療系統,2008 TiC100創新事業競賽--科技創新優質獎(全國第三名)(主要貢獻: 組隊隊長)

8.謝宗勳,國立成功大學優秀博士班研究生獎學金 (2006/09-2010/06)

9.梁仁溢、劉弛祐、謝宗勳、陳家進、陳孟意、葉明龍,經由踝關節運動分析於阿基里斯腱修復之功能性評估。第四屆國際虛擬互動式骨骼肌肉系統研討會--優秀論文海報第二名

10.梁仁溢、劉弛祐、謝宗勳、陳家進、陳孟意、葉明龍,利用步態分析系統與功能指數評估大鼠之阿基里斯腱功能性修復的敏感度:初步研究報告, 2009國際生物力學研討會暨生物力學年度學術研討會,優秀論文競賽-大會優等獎

11.陳威廷、張登慶、謝宗勳、李筱瑜,應用擴增實境於帕金森氏症患者步態之改善,2009生物醫學工程科技研討會--佳作(主要貢獻: 帶領碩士班參賽)

12.謝尚衡、謝宗勳、李志明、韓煥章、張登慶,吞嚥障礙評估及治療之新設計,2008全國大專院校生物醫學工程創意設計製作競賽--佳作(主要貢獻: 帶領碩士班參賽)

13.謝尚衡、謝宗勳、韓煥章、李志明、張登慶,智慧型吞嚥障礙治療系統,2008第四屆成大旗勝盃自然與工程組--銀牌獎(主要貢獻: 帶領碩士班參賽)

14.謝宗勳、謝尚衡、林儒聖、李志明,可攜式袖珍藍芽吞嚥量測系統,2007第三屆成大旗勝盃創意競賽自然與工程組--佳作(主要貢獻:組隊隊長)

15.張登慶、李筱瑜、謝宗勳、郭明達、陳家進,開發帕金森氏大鼠在虛擬環境下之頭部活動和步態分析系統,2007年生物醫學工程科技研討會壁報論文競賽--佳作(主要貢獻: 帶領碩士班參賽)

16.謝宗勳,獲國科會補助博士生出國參加國際會議: Australasian Winter Conference on Brain Research, Queenstown, New Zealand, 2007.

17.蔡健儀、吳宜寧、方志宏、謝宗勳、陳家進,痙孿性大白鼠之生物力學及肌電訊號評估,95年度醫學工程年會暨醫工科技研討會--生物力學組--優等論文